Marcel Mule (born 24 June 1901, Aube, France – died 18 December 2001) was a French classical saxophonist.

In 1927, Mule formed a saxophone quartet along with members of the , under the name of Quatuor de la Garde Républicaine. In its earliest stage (it was to last for some 40 years) there was no music for such groups. Mule transcribed the music of classical composers such as Albéniz (Sevilla from the Suite Española Op. 47) and Mozart. His new ensemble achieved critical acclaim early on. As a consequence, important composers of the day, including Gabriel Pierné, Florent Schmitt and Alexander Glazunov, contributed their own works to an ever-expanding repertoire for the instrument group. This influx of exciting new material proved essential for the establishment of the saxophone quartet as a viable, sustainable ensemble type.